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The antibody against PELO was raised in rabbit using the Recombinant Human Protein pelota homolog protein (1-385AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
The antibody against PELO was raised in rabbit using the Recombinant Human Protein pelota homolog protein (1-385AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
$299.00
| Cat.No | ADC-24112A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PELO |
| Target Synonyms | CGI 17 antibody; CGI17 antibody; pelo antibody; PELO_HUMAN antibody; pelota (Drosophila) homolog antibody; pelota homolog antibody; PRO1770 antibody; Protein pelota homolog antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | FITC conjugated | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein pelota homolog protein (1-385AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BRX2 |
Uniprot Id
Q9BRX2
Target Species
Human
Target Name
PELO
Target Full Name
Protein pelota homolog
Target Function
Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Protein Families
Eukaryotic release factor 1 family, Pelota subfamily
Target Tissue Specificity
Ubiquitously expressed.
Target Synonyms
CGI 17; CGI17; pelo; PELO_HUMAN; pelota (Drosophila) homolog ; pelota homolog ; PRO1770; Protein pelota homolog
Target Background
This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division.
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