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The antibody against PerCP/Cyanine5.5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 43-300 of human CD38 (NP_001766.2) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on FC.
The antibody against PerCP/Cyanine5.5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 43-300 of human CD38 (NP_001766.2) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on FC.
Flow cytometry: 1X10^6 Hep G2 cells (negative control, left)?and Daudi cells (right) were surface-stained with PerCP/Cyanine5.5 Rabbit anti-Human CD38 mAb or PerCP/Cyanine5.5 Rabbit IgG isotype control. Non-fluorescently stained cells were used as blank control (red line).
| Cat.No | ADA-08564A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PerCP/Cyanine5.5 |
| Target Synonyms | ADPRC1; cADPR1; ADPRC 1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.2% BSA, PBS with 0.03% proclin300, pH7.3. | Purification Method | Affinity purification |
| Application | FC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 43-300 of human CD38 (NP_001766.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P28907 | Immunogen Sequence |
Uniprot Id
P28907
Target Species
Human
Target Name
CD38
Target Full Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Target Function
Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Target Subcellular Location
Membrane; Single-pass type II membrane protein.
Target Protein Families
ADP-ribosyl cyclase family
Target Tissue Specificity
Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
Target Research Area
Cancer
Target Synonyms
CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD antigen CD38
Target Background
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.
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