Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The antibody against PES1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PES1 (NP_055118.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PES1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PES1 (NP_055118.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05596A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PES1 |
| Target Synonyms | PES; NOP7; PES1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HepG2, Jurkat, MCF7 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PES1 (NP_055118.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MGGLEKKKYERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIRFLLHEPIVNKFREYKVFVRKLRKAYGKSEWNTVERLKDNKPNYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRT | Uniprot ID | O00541 |
Uniprot Id
O00541
Target Species
Human
Target Name
PES1
Target Full Name
Pescadillo homolog
Target Function
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Target Subcellular Location
Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome.
Target Protein Families
Pescadillo family
Target Tissue Specificity
Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin.
Target Research Area
Cancer
Target Synonyms
FLJ43790; Homo sapiens pescadillo mRNA complete cds; PES; PES 1; pes1; PESC_HUMAN; Pescadillo (zebrafish) homolog 1 containing BRCT domain; Pescadillo homolog 1; Pescadillo homolog 1 containing BRCT domain (zebrafish); Pescadillo homolog; Pescadillo ribosomal biogenesis factor 1
Target Background
This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
