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The antibody against PGAM2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human PGAM2 (NP_000281.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against PGAM2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human PGAM2 (NP_000281.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-11738A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PGAM2 |
| Target Synonyms | GSD10; PGAMM; PGAM-M; PGAM2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, Rat brain, 22Rv1, Mouse skeletal muscle, Mouse testis, Rat kidney, Rat skeletal muscle, SH-SY5Y, U-87MG | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human PGAM2 (NP_000281.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P15259 | Immunogen Sequence |
Uniprot Id
P15259
Target Species
Human
Target Name
PGAM2
Target Full Name
Phosphoglycerate mutase 2
Target Function
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
Target Involvement
Glycogen storage disease 10 (GSD10)
Target Protein Families
Phosphoglycerate mutase family, BPG-dependent PGAM subfamily
Target Tissue Specificity
Expressed in the heart and muscle. Not found in the liver and brain.
Target Synonyms
BPG dependent PGAM 2; BPG-dependent PGAM 2; GSD10; MGC88743; Muscle specific phosphoglycerate mutase; Muscle-specific phosphoglycerate mutase; OTTHUMP00000207787; PGAM 2; PGAM M; PGAM-M; Pgam2; PGAM2_HUMAN; PGAMM; phosphoglycerate mutase 2 (muscle); Phosphoglycerate mutase 2; Phosphoglycerate mutase isozyme M
Target Background
Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X.
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