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The antibody against PGD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 184-483 of human PGD (NP_002622.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against PGD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 184-483 of human PGD (NP_002622.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-09290A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PGD |
| Target Synonyms | 6PGD; PGD | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, 293T, A-549, Mouse lung, Mouse spleen, Raji, Rat kidney | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 184-483 of human PGD (NP_002622.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P52209 | Immunogen Sequence |
Uniprot Id
P52209
Target Species
Human
Target Name
PGD
Target Full Name
6-phosphogluconate dehydrogenase, decarboxylating
Target Function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Target Subcellular Location
Cytoplasm.
Target Protein Families
6-phosphogluconate dehydrogenase family
Target Research Area
Metabolism
Target Synonyms
0610042A05Rik; 6 phosphogluconate dehydrogenase; decarboxylating; 6-phosphogluconate dehydrogenase; 6PGD; 6PGD_HUMAN; AU019875; C78335; decarboxylating; OTTMUSP00000011754; Pgd; Phosphogluconate dehydrogenase; RP23-249G3.4
Target Background
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene.
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