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The antibody against PHF20 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 140-380 of human PHF20 (NP_057520.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PHF20 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 140-380 of human PHF20 (NP_057520.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00975A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PHF20 |
| Target Synonyms | NZF; TZP; GLEA2; HCA58; TDRD20A; C20orf104; PHF20 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Jurkat | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 140-380 of human PHF20 (NP_057520.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BVI0 | Immunogen Sequence |
Uniprot Id
Q9BVI0
Target Species
Human
Target Name
PHF20
Target Full Name
PHD finger protein 20
Target Function
Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Expressed in heart, kidney, liver, lung, pancreas, placenta, spleen and testis. Not expressed in brain, skeletal muscle, colon, ovary, prostate, small intestine and thymus. Expressed in colon and ovary cancer cell lines while it is not expressed in the re
Target Synonyms
C20orf104; GLEA2; Glioma-expressed antigen 2; HCA58; Hepatocellular carcinoma-associated antigen 58; Novel zinc finger protein; NZF; PHD finger protein 20; PHF20; PHF20_HUMAN; Transcription factor TZP; TZP
Target Background
Predicted to enable DNA binding activity and metal ion binding activity. Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in cytosol; nuclear membrane; and nucleoplasm. Part of MLL1 complex and histone acetyltransferase complex.
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