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Rabbit anti-Human PHIP Polyclonal Antibody, Biotin conjugated

The antibody against PHIP was raised in rabbit using the Recombinant Human PH-interacting protein (508-608AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

ADC-13726A

The antibody against PHIP was raised in rabbit using the Recombinant Human PH-interacting protein (508-608AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.

$299.00

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Specifications


Cat.No ADC-13726A ClonalityPolyclonal
Host SpeciesRabbitTarget NamePHIP
FormLiquidSpecies ReactivityHuman
IsotypeIgGStorage Buffer0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4
Purification Method>95%, Protein G purifiedConjugateBiotin conjugated
ApplicationELISAStorageUpon receipt

Immunogen Information


Immunogen DescriptionRecombinant Human PH-interacting protein (508-608AA)Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDQ8WWQ0
Background Information
  • Uniprot Id

    Q8WWQ0

  • Target Species

    Human

  • Target Name

    PHIP

  • Target Full Name

    PH-interacting protein

  • Target Function

    Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.

  • Target Subcellular Location

    Nucleus.

  • Target Tissue Specificity

    Expressed in myeloma and epidermoid carcinoma cell lines.

  • Target Synonyms

    PHIP; DCAF14; WDR11; PH-interacting protein; PHIP; DDB1- and CUL4-associated factor 14; IRS-1 PH domain-binding protein; WD repeat-containing protein 11

  • Target Background

    This gene encodes a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promote melanoma metastasis in human patients.

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