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The antibody against PHLDA3 was raised in rabbit using the Recombinant Human Pleckstrin homology-like domain family A member 3 protein (43-95AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against PHLDA3 was raised in rabbit using the Recombinant Human Pleckstrin homology-like domain family A member 3 protein (43-95AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human liver using PHLDA3 Antibody at dilution of 1:100
| Cat.No | ADC-12517A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PHLDA3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Pleckstrin homology-like domain family A member 3 protein (43-95AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y5J5 |
Uniprot Id
Q9Y5J5
Target Species
Human
Target Name
PHLDA3
Target Full Name
Pleckstrin homology-like domain family A member 3
Target Function
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
Target Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein.
Target Protein Families
PHLDA3 family
Target Tissue Specificity
Widely expressed with lowest expression in liver and spleen.
Target Synonyms
PHLA3_HUMAN; PHLDA 3; phlda3; Pleckstrin homology like domain family A member 2; Pleckstrin homology like domain family A member 3; Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1; TDAG51/Ipl homologue 1; TIH 1; TIH1
Target Background
Enables phosphatidylinositol phosphate binding activity and phosphatidylinositol-3, 4-bisphosphate binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of protein kinase B signaling; and positive regulation of apoptotic process. Located in plasma membrane.
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