Name: Rabbit anti-Human Phospho-ACO1 (S711) Polyclonal Antibody
SKU: ADC-34889A
Availability: InStock

Rabbit anti-Human Phospho-ACO1 (S711) Polyclonal Antibody

The antibody against ACO1 was raised in rabbit using the Synthesized peptide derived from Human IRP-1 around the phosphorylation site of S711. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.

ADC-34889A

$167.00

Number

Cat.No

ADC-34889A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ACO1

Form

Liquid

Species Reactivity

Human, Mouse, Rat, Monkey

Isotype

IgG

Storage Buffer

0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate

Non-conjugated

Application

ELISA, IHC, WB

Storage

Upon receipt

Immunogen Description

Synthesized peptide derived from Human IRP-1 around the phosphorylation site of S711.

Target Species

Human

Immunogen Sequence

Complete sequences for the immunogen, target protein, and peptides are available upon request.

Uniprot ID

P21399

Background Information

Uniprot Id

P21399
Target Species

Human
Target Name

ACO1
Target Full Name

Cytoplasmic aconitate hydratase
Target Function

Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA.; Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
Target Subcellular Location

Cytoplasm, cytosol.
Target Protein Families

Aconitase/IPM isomerase family
Target Synonyms

ACO 1; ACO1; ACOC_HUMAN; Aconitase 1 soluble; Aconitase; Aconitase1; Aconitate hydratase; ACONS; Citrate hydro lyase; Citrate hydro-lyase; Cytoplasmic aconitate hydratase; Ferritin repressor protein; IRE BP 1; IRE-BP 1; IREB 1; IREB1; IREBP; IREBP1; Iron regulatory protein 1; Iron responsive element binding protein 1; Iron-responsive element-binding protein 1; IRP 1; IRP1; OTTHUMP00000045233
Target Background

The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants

Rabbit anti-Human Phospho-ACO1 (S711) Polyclonal Antibody

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