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The antibody against CCNE2 was raised in rabbit using the Synthesized peptide derived from Human Cyclin E2 around the phosphorylation site of T392. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IF, ELISA.
The antibody against CCNE2 was raised in rabbit using the Synthesized peptide derived from Human Cyclin E2 around the phosphorylation site of T392. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IF, ELISA.
$167.00
| Cat.No | ADC-33370A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CCNE2 |
| Target Synonyms | CCNE2 antibody; G1/S-specific cyclin-E2 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IF |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from Human Cyclin E2 around the phosphorylation site of T392. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O96020 |
Uniprot Id
O96020
Target Species
Human
Target Name
CCNE2
Target Full Name
G1/S-specific cyclin-E2
Target Function
Essential for the control of the cell cycle at the late G1 and early S phase.
Target Subcellular Location
Nucleus.
Target Protein Families
Cyclin family, Cyclin E subfamily
Target Tissue Specificity
According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubM
Target Synonyms
CCNE2; G1/S-specific cyclin-E2
Target Background
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.
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