Rabbit anti-Human Phospho-KRAS-S89 Polyclonal Antibody

The antibody against Phospho-KRAS-S89 was raised in Rabbit using a synthetic phosphorylated peptide around S89 of human KRAS (NP_001356715.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-00804A

Number

Cat.No	ADA-00804A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	Phospho-KRAS-S89
Target Synonyms	NS; NS3; OES; CFC2; RALD; K-Ras; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; K-Ras 2; 'C-K-RAS; c-Ki-ras; c-Ki-ras2; Phospho-KRAS-S89	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	NIH/3T3, Jurkat	Application	ELISA, WB, IHC-P

Cat.No

ADA-00804A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

Phospho-KRAS-S89

Target Synonyms

NS; NS3; OES; CFC2; RALD; K-Ras; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; K-Ras 2; 'C-K-RAS; c-Ki-ras; c-Ki-ras2; Phospho-KRAS-S89

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

NIH/3T3, Jurkat

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic phosphorylated peptide around S89 of human KRAS (NP_001356715.1).	Target Species	Human
Immunogen Sequence	TKSFE	Uniprot ID	P01116

Immunogen Description

A synthetic phosphorylated peptide around S89 of human KRAS (NP_001356715.1).

Target Species

Human

Immunogen Sequence

TKSFE

Uniprot ID

P01116

Background Information

Uniprot Id

P01116
Target Species

Human
Target Name

KRAS
Target Full Name

GTPase KRas
Target Function

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.
Target Involvement

Leukemia, acute myelogenous (AML); Leukemia, juvenile myelomonocytic (JMML); Noonan syndrome 3 (NS3); Gastric cancer (GASC); Cardiofaciocutaneous syndrome 2 (CFC2)
Target Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol.; [Isoform 2B]: Cell membrane; Lipid-anchor.
Target Protein Families

Small GTPase superfamily, Ras family
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

c Ki ras2; c Kirsten ras protein; c-K-ras; c-Ki-ras; Cellular c Ki ras2 proto oncogene; Cellular transforming proto oncogene; CFC2; cK Ras; GTPase KRas; K RAS p21 protein; K RAS2A; K RAS2B; K RAS4A; K RAS4B; K-Ras 2; KI RAS; Ki-Ras; KIRSTEN MURINE SARCOMA VIRUS 2; Kirsten rat sarcoma 2 viral (v Ki ras2) oncogene homolog; Kirsten rat sarcoma viral oncogene homolog; KRAS; KRAS proto oncogene, GTPase; KRAS1; KRAS2; N-terminally processed; NS; NS3; Oncogene KRAS2; p21ras; PR310 c K ras oncogene; PR310 cK ras oncogene; RALD; RASK_HUMAN; RASK2; Transforming protein p21; v Ki ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v Ki ras2 Kirsten rat sarcoma viral oncogene homolog
Target Background

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.

Rabbit anti-Human Phospho-KRAS-S89 Polyclonal Antibody

Specifications

Immunogen Information

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