Rabbit anti-Human Phospho-STAT5A-Y694 Monoclonal Antibody

Uniprot Id

P42229

Target Species

Human

Target Name

STAT5A

Target Full Name

Signal transducer and activator of transcription 5A

Target Function

Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.

Target Subcellular Location

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Target Protein Families

Transcription factor STAT family

Target Synonyms

MGF; Signal transducer and activator of transcription 5A; Signal Transducer and Activator of Transcription 5B; STA5A_HUMAN; STAT 5A; STAT 5B; STAT5; STAT5A; STAT5B; Transcription factor STAT5A; Transcription factor STAT5B

Target Background

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.