Rabbit anti-Human PI3 Polyclonal Antibody

The antibody against PI3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 23-117 of human PI3 (NP_002629.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-11199A

Number

Cat.No	ADA-11199A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PI3
Target Synonyms	ESI; WAP3; SKALP; WFDC14; cementoin; PI3	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HepG2, U-87MG	Application	ELISA, WB, IHC-P

Cat.No

ADA-11199A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PI3

Target Synonyms

ESI; WAP3; SKALP; WFDC14; cementoin; PI3

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HepG2, U-87MG

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 23-117 of human PI3 (NP_002629.1).	Target Species	Human
Immunogen Sequence	AVTGVPVKGQDTVKGRVPFNGQDPVKGQVSVKGQDKVKAQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCCEGSCGMACFVPQ	Uniprot ID	P19957

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 23-117 of human PI3 (NP_002629.1).

Target Species

Human

Immunogen Sequence

AVTGVPVKGQDTVKGRVPFNGQDPVKGQVSVKGQDKVKAQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCCEGSCGMACFVPQ

Uniprot ID

P19957

Background Information

Uniprot Id

P19957
Target Species

Human
Target Name

PI3
Target Full Name

Elafin
Target Function

Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1).
Target Subcellular Location

Secreted.
Target Research Area

Signal Transduction
Target Synonyms

Cementoin; ELAF_HUMAN; Elafin; Elafin/Skalp; Elastase Specific Inhibitor; Elastase-specific inhibitor; ES 1; ESI; Peptidase inhibitor 3; Peptidase inhibitor 3; skin derived; PI 3; PI-3; PI3; Pre elafin; Protease inhibitor 3 skin derived ; Protease inhibitor 3; skin derived (SKALP); Protease inhibitor WAP3; SKALP; Skin derived Anti leukoproteinase; Skin-derived antileukoproteinase; Trappin 2; WAP four disulfide core domain 14; WAP four disulfide core domain protein 14; WAP four-disulfide core domain protein 14; WAP3; WFDC14
Target Background

This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.

Rabbit anti-Human PI3 Polyclonal Antibody

Specifications

Immunogen Information

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