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The antibody against PIGO was raised in rabbit using the Recombinant Human GPI ethanolamine phosphate transferase 3 protein (219-420AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against PIGO was raised in rabbit using the Recombinant Human GPI ethanolamine phosphate transferase 3 protein (219-420AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human kidney tissue using PIGO Antibody at dilution of 1:100
Immunofluorescent analysis of A549 cells using PIGO Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-24085A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PIGO |
| Target Synonyms | PIGO antibody; UNQ632/PRO1249 antibody; GPI ethanolamine phosphate transferase 3 antibody; EC 2.-.-.- antibody; Phosphatidylinositol-glycan biosynthesis class O protein antibody; PIG-O antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human GPI ethanolamine phosphate transferase 3 protein (219-420AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8TEQ8 |
Uniprot Id
Q8TEQ8
Target Species
Human
Target Name
PIGO
Target Full Name
GPI ethanolamine phosphate transferase 3
Target Function
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond.
Target Involvement
Hyperphosphatasia with mental retardation syndrome 2 (HPMRS2)
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
PIGG/PIGN/PIGO family, PIGO subfamily
Target Synonyms
PIGO; UNQ632/PRO1249; GPI ethanolamine phosphate transferase 3; EC 2.-.-.-; Phosphatidylinositol-glycan biosynthesis class O protein; PIG-O
Target Background
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene.
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