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The antibody against PIP4P2 was raised in rabbit using the Recombinant Human Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase protein (1-191AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against PIP4P2 was raised in rabbit using the Recombinant Human Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase protein (1-191AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human lung cancer using PIP4P2 Antibody at dilution of 1:1002
| Cat.No | ADC-23226A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PIP4P2 |
| Target Synonyms | 5-bisphosphate 4-phosphatase; Type 2 PtdIns-4, 5-P2 4-Ptase II; Transmembrane protein 55A, 5-P2 4-Ptase; PtdIns-4, PIP4P2; TMEM55A; Type 2 phosphatidylinositol 4 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase protein (1-191AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N4L2 |
Uniprot Id
Q8N4L2
Target Species
Human
Target Name
PIP4P2
Target Full Name
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Target Function
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation.
Target Subcellular Location
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Target Tissue Specificity
Ubiquitous.
Target Synonyms
PIP4P2; TMEM55A; Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Type 2 PtdIns-4,5-P2 4-Ptase; PtdIns-4,5-P2 4-Ptase II; Transmembrane protein 55A
Target Background
TMEM55A catalyzes the degradation of phosphatidylinositol 4, 5-bisphosphate (PtdIns-4, 5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).
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