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The antibody against PKLR was raised in rabbit using the Recombinant Human Pyruvate kinase PKLR protein (1-574AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against PKLR was raised in rabbit using the Recombinant Human Pyruvate kinase PKLR protein (1-574AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-21700A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PKLR |
| Target Synonyms | red cell type antibody; R type/L type pyruvate kinase antibody; R-PK antibody; R-type/L-type pyruvate kinase antibody; Red cell/liver pyruvate kinase antibody; RPK antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Pyruvate kinase PKLR protein (1-574AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P30613 |
Uniprot Id
P30613
Target Species
Human
Target Name
PKLR
Target Full Name
Pyruvate kinase PKLR
Target Function
Plays a key role in glycolysis.
Target Involvement
Pyruvate kinase hyperactivity (PKHYP); Pyruvate kinase deficiency of red cells (PKRD)
Target Protein Families
Pyruvate kinase family
Target Research Area
Metabolism
Target Synonyms
EC 2.7.1.40; KPYR_HUMAN; L-PK; Pk-1; PK1 ; PKL ; Pklg; Pklr; PKR; PKRL; Pyruvate kinase 1; Pyruvate kinase isozymes R/L; Pyruvate kinase liver and blood cell; Pyruvate kinase liver and RBC; Pyruvate kinase liver and red blood cell; Pyruvate kinase liver type; Pyruvate kinase type L; Pyruvate kinase, red cell type; R type/L type pyruvate kinase; R-PK; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase; RPK
Target Background
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.
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