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The antibody against PKP2 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human Plakophilin 2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against PKP2 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human Plakophilin 2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
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Western Blot analysis of HepG2 cells using Plakophilin 2 Polyclonal Antibody
Western Blot analysis of Jurakt 293 cells using Plakophilin 2 Polyclonal Antibody2
| Cat.No | ADC-37823A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PKP2 |
| Target Synonyms | ARVD 9 antibody; ARVD9 antibody; PKP 2 antibody; PKP2 antibody; PKP2_HUMAN antibody; Plakophilin-2 antibody; Plakophilin2 antibody | Form | Liquid |
| Species Reactivity | Human, Rat | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the C-terminal region of Human Plakophilin 2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q99959 |
Uniprot Id
Q99959
Target Species
Human
Target Name
PKP2
Target Full Name
Plakophilin-2
Target Function
May play a role in junctional plaques.
Target Involvement
Arrhythmogenic right ventricular dysplasia, familial, 9 (ARVD9)
Target Subcellular Location
Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes.
Target Protein Families
Beta-catenin family
Target Tissue Specificity
Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the des
Target Synonyms
ARVD 9; ARVD9; PKP 2; PKP2; PKP2_HUMAN; Plakophilin-2; Plakophilin2
Target Background
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. Mutations in this gene are associated with different inherited cardiac conditions including Arrythmogenic Cardiomyopathy, Brugada Syndrome, and Idiopathic Ventricular Fibrillation. A processed pseudogene with high similarity to this gene has been mapped to chromosome 12p13.
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