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The antibody against PLAA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 536-795 of human PLAA (NP_001026859.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PLAA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 536-795 of human PLAA (NP_001026859.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03976A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PLAA |
| Target Synonyms | DOA1; PLAP; PLA2P; NDMSBA; PLAA | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-549, HT-1080, Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 536-795 of human PLAA (NP_001026859.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y263 | Immunogen Sequence |
Uniprot Id
Q9Y263
Target Species
Human
Target Name
PLAA
Target Full Name
Phospholipase A-2-activating protein
Target Function
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
Target Involvement
Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies (NDMSBA)
Target Subcellular Location
Nucleus. Cytoplasm. Cell junction, synapse.
Target Protein Families
WD repeat PLAP family
Target Synonyms
DOA1; PLAP; PLA2P; NDMSBA; PLAA
Target Background
Predicted to enable ubiquitin binding activity. Involved in cellular response to lipopolysaccharide; macroautophagy; and positive regulation of phospholipase A2 activity. Located in cytoplasm; extracellular exosome; and nucleus.
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