Rabbit anti-Human PLCL1 Polyclonal Antibody

Uniprot Id

Q15111

Target Species

Human

Target Name

PLCL1

Target Full Name

Inactive phospholipase C-like protein 1

Target Function

Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.

Target Subcellular Location

Cytoplasm.

Target Tissue Specificity

Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.

Target Synonyms

Inactive phospholipase C-like protein 1; Inactive protein 1; Phospholipase C deleted in lung carcinoma; Phospholipase C epsilon; Phospholipase C like 1; Phospholipase C related but catalytically inactive protein; Phospholipase C related, but catalytically inactive protein; Phospholipase C-deleted in lung carcinoma; Phospholipase C-related but catalytically inactive protein; Phospholipase C-related catalytically; PLC-L1; PLCE; PLCL; PLCL1; PLCL1_HUMAN; PLDL1; PRIP

Target Background

Predicted to enable phospholipase C activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within several processes, including gamma-aminobutyric acid signaling pathway; regulation of GABAergic synaptic transmission; and regulation of peptidyl-serine phosphorylation. Predicted to be located in cytoplasm and plasma membrane.