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The antibody against PLCL1 was raised in rabbit using the Recombinant Human Inactive phospholipase C-like protein 1 protein (1-108AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against PLCL1 was raised in rabbit using the Recombinant Human Inactive phospholipase C-like protein 1 protein (1-108AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-04089A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PLCL1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Inactive phospholipase C-like protein 1 protein (1-108AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15111 |
Uniprot Id
Q15111
Target Species
Human
Target Name
PLCL1
Target Full Name
Inactive phospholipase C-like protein 1
Target Function
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.
Target Synonyms
Inactive phospholipase C-like protein 1; Inactive protein 1; Phospholipase C deleted in lung carcinoma; Phospholipase C epsilon; Phospholipase C like 1; Phospholipase C related but catalytically inactive protein; Phospholipase C related, but catalytically inactive protein; Phospholipase C-deleted in lung carcinoma; Phospholipase C-related but catalytically inactive protein; Phospholipase C-related catalytically; PLC-L1; PLCE; PLCL; PLCL1; PLCL1_HUMAN; PLDL1; PRIP
Target Background
Predicted to enable phospholipase C activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within several processes, including gamma-aminobutyric acid signaling pathway; regulation of GABAergic synaptic transmission; and regulation of peptidyl-serine phosphorylation. Predicted to be located in cytoplasm and plasma membrane.
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