Rabbit anti-Human PLD4 Polyclonal Antibody

The antibody against PLD4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 52-200 of human PLD4 (NP_620145.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-05213A

Number

Cat.No	ADA-05213A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PLD4
Target Synonyms	C14orf175; PLD4	Form	Liquid
Species Reactivity	Human, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	K-562, Rat lung, Rat spleen, Rat thymus	Application	ELISA, WB

Cat.No

ADA-05213A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PLD4

Target Synonyms

C14orf175; PLD4

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

K-562, Rat lung, Rat spleen, Rat thymus

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 52-200 of human PLD4 (NP_620145.2).	Target Species	Human
Immunogen Sequence	WQVPRPPTWGQVQPKDVPRSWEHGSSPAWEPLEAEARQQRDSCQLVLVESIPQDLPSAAGSPSAQPLGQAWLQLLDTAQESVHVASYYWSLTGPDIGVNDSSSQLGEALLQKLQQLLGRNISLAVATSSPTLARTSTDLQVLAARGAHV	Uniprot ID	Q96BZ4

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 52-200 of human PLD4 (NP_620145.2).

Target Species

Human

Immunogen Sequence

WQVPRPPTWGQVQPKDVPRSWEHGSSPAWEPLEAEARQQRDSCQLVLVESIPQDLPSAAGSPSAQPLGQAWLQLLDTAQESVHVASYYWSLTGPDIGVNDSSSQLGEALLQKLQQLLGRNISLAVATSSPTLARTSTDLQVLAARGAHV

Uniprot ID

Q96BZ4

Background Information

Uniprot Id

Q96BZ4
Target Species

Human
Target Name

PLD4
Target Full Name

5'-3' exonuclease PLD4
Target Function

5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia.
Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Nucleus. Early endosome. Cytoplasmic vesicle, phagosome.
Target Protein Families

Phospholipase D family
Target Research Area

Cardiovascular
Target Synonyms

C14orf175; Choline phosphatase 4; EC 3.1.4.4; Phosphatidylcholine hydrolyzing phospholipase D4; Phosphatidylcholine-hydrolyzing phospholipase D4; Phospholipase D family member 4; Phospholipase D4; PLD 4; PLD4; PLD4_HUMAN
Target Background

Predicted to enable single-stranded DNA 5'-3' exodeoxyribonuclease activity. Predicted to be involved in hematopoietic progenitor cell differentiation; phagocytosis; and regulation of cytokine production involved in inflammatory response. Predicted to be located in early endosome and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; phagocytic vesicle; and trans-Golgi network membrane.

Rabbit anti-Human PLD4 Polyclonal Antibody

Specifications

Immunogen Information

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