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The antibody against PLEKHG4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 710-1010 of human PLEKHG4 (NP_001123199.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PLEKHG4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 710-1010 of human PLEKHG4 (NP_001123199.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04635A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PLEKHG4 |
| Target Synonyms | SCA4; PRTPHN1; ARHGEF44; PLEKHG4 | Form | Liquid |
| Species Reactivity | Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat testis | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 710-1010 of human PLEKHG4 (NP_001123199.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q58EX7 | Immunogen Sequence |
Uniprot Id
Q58EX7
Target Species
Human
Target Name
PLEKHG4
Target Full Name
Puratrophin-1
Target Function
Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi.
Target Tissue Specificity
Expressed in kidney, Leydig cells in the testis, epithelial cells in the prostate gland and Langerhans islet in the pancreas. Isoform 1 and isoform 3 are strongly expressed in Purkinje cells and to a lower extent in other neurons (at protein level). Widel
Target Synonyms
ARHGEF44; DKFZp434I216; PH domain containing family G member 4; PH domain-containing family G member 4; PKHG4_HUMAN; Pleckstrin homology and RhoGEF domain containing G4; Pleckstrin homology domain containing family G (with RhoGef domain) member 4; Pleckstrin homology domain containing family G member 4; Pleckstrin homology domain-containing family G member 4; PLEKHG 4; PLEKHG4; PRTPHN 1; PRTPHN1; Puratrophin 1; Puratrophin-1; Puratrophin1; Purkinje cell atrophy associated protein 1; Purkinje cell atrophy-associated protein 1; SCA 4; SCA4
Target Background
The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants.
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