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The antibody against PLEKHG5 was raised in rabbit using the Human PLEKHG5 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against PLEKHG5 was raised in rabbit using the Human PLEKHG5 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-52332A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PLEKHG5 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.02% sodium azide |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Human PLEKHG5 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O94827 |
Uniprot Id
O94827
Target Species
Human
Target Name
PLEKHG5
Target Full Name
Pleckstrin homology domain-containing family G member 5
Target Function
Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts.
Target Involvement
Distal spinal muscular atrophy, autosomal recessive, 4 (DSMA4); Charcot-Marie-Tooth disease, recessive, intermediate type, C (CMTRIC)
Target Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Cell junction. Cell projection, lamellipodium.
Target Tissue Specificity
Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (G
Target Synonyms
PLEKHG5; KIAA0720; Pleckstrin homology domain-containing family G member 5; PH domain-containing family G member 5; Guanine nucleotide exchange factor 720; GEF720
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