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The antibody against PLXNB2 was raised in rabbit using the Synthetic peptide of Human PLXNB2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against PLXNB2 was raised in rabbit using the Synthetic peptide of Human PLXNB2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-26129A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PLXNB2 |
| Target Synonyms | PLXNB2 antibody; KIAA0315 antibody; Plexin-B2 antibody; MM1 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human PLXNB2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O15031 |
Uniprot Id
O15031
Target Species
Human
Target Name
PLXNB2
Target Full Name
Plexin-B2
Target Function
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Plexin family
Target Research Area
Neuroscience
Target Synonyms
PLXNB2; KIAA0315; Plexin-B2; MM1
Target Background
Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).
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