Rabbit anti-Human PLZF Monoclonal Antibody

Uniprot Id

Q05516

Target Species

Human

Target Name

ZBTB16

Target Full Name

Zinc finger and BTB domain-containing protein 16

Target Function

Acts as a transcriptional repressor. Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Target Involvement

Skeletal defects, genital hypoplasia, and mental retardation (SGYMR)

Target Subcellular Location

Nucleus. Nucleus, nuclear body.

Target Protein Families

Krueppel C2H2-type zinc-finger protein family

Target Tissue Specificity

Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.

Target Synonyms

PLZF; ZNF145

Target Background

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.