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The antibody against PMPCA was raised in rabbit using the Recombinant Human Mitochondrial-processing peptidase subunit alpha protein (456-525AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against PMPCA was raised in rabbit using the Recombinant Human Mitochondrial-processing peptidase subunit alpha protein (456-525AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human colon cancer using PMPCA Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human endometrial cancer using PMPCA Antibody at dilution of 1:1002
| Cat.No | ADC-16244A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PMPCA |
| Target Synonyms | 1200002L24Rik antibody; 4933435E07Rik antibody; Alpha MPP antibody; Alpha-MPP antibody; FLJ26258 antibody; Inositol polyphosphate 5 phosphatase, 72 kD antibody; INPP5E antibody; KIAA0123 antibody; MGC104197 antibody; MGC93916 antibody; Mitochondrial matrix processing protease | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Mitochondrial-processing peptidase subunit alpha protein (456-525AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q10713 |
Uniprot Id
Q10713
Target Species
Human
Target Name
PMPCA
Target Full Name
Mitochondrial-processing peptidase subunit alpha
Target Function
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
Target Involvement
Spinocerebellar ataxia, autosomal recessive, 2 (SCAR2)
Target Subcellular Location
Mitochondrion matrix. Mitochondrion inner membrane.
Target Protein Families
Peptidase M16 family
Target Tissue Specificity
Ubiquitously expressed with highest expression in fetal tissues and adult brain, cerebellum and cerebellar vermis.
Target Synonyms
1200002L24Rik; 4933435E07Rik; Alpha MPP; Alpha-MPP; FLJ26258; Inositol polyphosphate 5 phosphatase, 72 kD; INPP5E; KIAA0123; MGC104197; MGC93916; Mitochondrial matrix processing protease, alpha subunit; mitochondrial processing peptidase subunit alpha; Mitochondrial-processing peptidase subunit alpha; MPPA_HUMAN; P 55; P-55; Peptidase (mitochondrial processing) alpha; pmpca; RP11-413M3.1; RP23-306D20.8; SCAR2
Target Background
The protein encoded by this gene is found in the mitochondrion, where it represents the alpha subunit of a proteolytic heterodimer. This heterodimer is responsible for cleaving the transit peptide from nuclear-encoded mitochondrial proteins. Defects in this gene are a cause of spinocerebellar ataxia, autosomal recessive 2.
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