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The antibody against PMPCB was raised in rabbit using the Recombinant Human Mitochondrial-processing peptidase subunit beta protein (110-380AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against PMPCB was raised in rabbit using the Recombinant Human Mitochondrial-processing peptidase subunit beta protein (110-380AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-16636A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PMPCB |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Mitochondrial-processing peptidase subunit beta protein (110-380AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O75439 |
Uniprot Id
O75439
Target Species
Human
Target Name
PMPCB
Target Full Name
Mitochondrial-processing peptidase subunit beta
Target Function
Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2. Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis.
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
Peptidase M16 family
Target Research Area
Cancer
Target Synonyms
Beta MPP; Beta-MPP; BetaMPP; Mitochondrial processing peptidase subunit beta; Mitochondrial-processing peptidase subunit beta; MPP11; MPPB; MPPB_HUMAN; MPPP52; P 52; P-52; P52; Peptidase mitichondrial processing beta; PMPCB
Target Background
This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex.
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