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The antibody against PNKD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PNKD (NP_056303.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against PNKD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PNKD (NP_056303.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-00021A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PNKD |
| Target Synonyms | R1; MR1; PDC; DYT8; FPD1; MR-1; BRP17; MR-1S; PKND1; PNKD1; FKSG19; TAHCCP2; KIPP1184; PNKD | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, 22Rv1, A-549, Mouse brain, THP-1 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PNKD (NP_056303.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8N490 | Immunogen Sequence |
Uniprot Id
Q8N490
Target Species
Human
Target Name
PNKD
Target Full Name
Probable hydrolase PNKD
Target Function
Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway.
Target Involvement
Dystonia 8 (DYT8)
Target Subcellular Location
[Isoform 1]: Membrane; Peripheral membrane protein.; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Mitochondrion.
Target Protein Families
Metallo-beta-lactamase superfamily, Glyoxalase II family
Target Tissue Specificity
Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. Variant Val-7 and Val-9 are detected in the brain only.
Target Synonyms
2210013N15Rik; 2810403H05Rik; AI854243; BRAIN PROTEIN 17; BRP17; DYT8; FKSG19; FPD1; KIAA1184; KIPP1184; MNCb-5687; MR-1; MR1; Myofibrillogenesis regulator 1; Paroxysmal nonkinesiogenic dyskinesia protein; PDC; PKND1; Pnkd; PNKD_HUMAN; Probable hydrolase PNKD; TAHCCP2; Trans-activated by hepatitis C virus core protein 2
Target Background
This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants.
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