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The antibody against PNPLA1 was raised in rabbit using the Recombinant Human Patatin-like phospholipase domain-containing protein 1 protein (101-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against PNPLA1 was raised in rabbit using the Recombinant Human Patatin-like phospholipase domain-containing protein 1 protein (101-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human kidney tissue using PNPLA1 Antibody at dilution of 1:1002
| Cat.No | ADC-18800A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PNPLA1 |
| Target Synonyms | PNPLA1 antibody; Patatin-like phospholipase domain-containing protein 1 antibody; EC 3.1.1.- antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Patatin-like phospholipase domain-containing protein 1 protein (101-300AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N8W4 |
Uniprot Id
Q8N8W4
Target Species
Human
Target Name
PNPLA1
Target Full Name
Omega-hydroxyceramide transacylase
Target Function
Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation. Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide. Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function. These lipids also play a role in keratinocyte differentiation. May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS).
Target Involvement
Ichthyosis, congenital, autosomal recessive 10 (ARCI10)
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Expressed in the digestive system. Expressed in the epidermis of skin keratinocytes. Strongly expressed in the granular layer. Expressed in the upper epidermis and eccrine sweat glands of the dermis and in the region of keratin filament bundles, which is
Target Synonyms
PNPLA1; Patatin-like phospholipase domain-containing protein 1; EC 3.1.1.-
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