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The antibody against PNPO was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human PNPO (NP_060599.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against PNPO was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human PNPO (NP_060599.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-11116A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PNPO |
| Target Synonyms | PDXPO; HEL-S-302; PNPO | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, Rat brain, 293T, HepG2, Mouse brain, Mouse liver, Rat kidney, Rat liver | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human PNPO (NP_060599.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NVS9 | Immunogen Sequence |
Uniprot Id
Q9NVS9
Target Species
Human
Target Name
PNPO
Target Full Name
Pyridoxine-5'-phosphate oxidase
Target Function
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Target Involvement
Pyridoxine-5'-phosphate oxidase deficiency (PNPOD)
Target Protein Families
Pyridoxamine 5'-phosphate oxidase family
Target Synonyms
EC 1.4.3.5; FLJ10535; PDXPO; PNPO; PNPO_HUMAN; Pyridoxal 5' phosphate synthase; pyridoxamine 5' phosphate oxidase; Pyridoxamine phosphate oxidase ; Pyridoxamine-phosphate oxidase; pyridoxine 5' phosphate oxidase; Pyridoxine-5'-phosphate oxidase
Target Background
The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy.
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