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The antibody against POLR2G was raised in rabbit using the Recombinant Human DNA-directed RNA polymerase II subunit RPB7 protein (1-172AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against POLR2G was raised in rabbit using the Recombinant Human DNA-directed RNA polymerase II subunit RPB7 protein (1-172AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
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Western Blot_x000D_ | Positive WB detected in: A549 whole cell lysate, K562 whole cell lysate, HL60 whole cell lysate_x000D_ | All lanes: POLR2G antibody at 1:2000_x000D_ | Secondary_x000D_ | Goat polyclonal to rabbit IgG at 1/50000 dilution_x000D_ | Predicted band size: 20 kDa_x000D_ | Observed band size: 20 kDa
| Cat.No | ADC-01881A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | POLR2G |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human DNA-directed RNA polymerase II subunit RPB7 protein (1-172AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P62487 |
Uniprot Id
P62487
Target Species
Human
Target Name
POLR2G
Target Full Name
DNA-directed RNA polymerase II subunit RPB7
Target Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Binds RNA.
Target Subcellular Location
Nucleus.
Target Protein Families
Eukaryotic RPB7/RPC8 RNA polymerase subunit family
Target Synonyms
DNA directed RNA polymerase II 19 kDa polypeptide ; DNA directed RNA polymerase II subunit G; DNA directed RNA polymerase II subunit RPB7; DNA-directed RNA polymerase II subunit G; DNA-directed RNA polymerase II subunit RPB7; hRPB19; hsRPB7; MGC138367; MGC138369; POLR2G; polymerase (RNA) II (DNA directed) polypeptide G; RNA polymerase II 19 kDa subunit; RNA polymerase II subunit B7; RPB19; RPB7 ; RPB7_HUMAN
Target Background
This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation.
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