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The antibody against PON3 was raised in rabbit using the Recombinant Human Serum paraoxonase/lactonase 3 protein (269-335AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against PON3 was raised in rabbit using the Recombinant Human Serum paraoxonase/lactonase 3 protein (269-335AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-06660A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PON3 |
| Target Synonyms | 2810004E20 antibody; AI786302 antibody; MGC95026 antibody; Paraoxonase 3 antibody; Pon3 antibody; PON3_HUMAN antibody; Serum paraoxonase/lactonase 3 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Serum paraoxonase/lactonase 3 protein (269-335AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15166 |
Uniprot Id
Q15166
Target Species
Human
Target Name
PON3
Target Full Name
Serum paraoxonase/lactonase 3
Target Function
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
Target Subcellular Location
Secreted, extracellular space.
Target Protein Families
Paraoxonase family
Target Synonyms
2810004E20; AI786302; MGC95026; Paraoxonase 3; Pon3; PON3_HUMAN; Serum paraoxonase/lactonase 3
Target Background
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.
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