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The antibody against PPIH was raised in rabbit using the Human PPIH as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against PPIH was raised in rabbit using the Human PPIH as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-52279A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PPIH |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Human PPIH | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O43447 |
Uniprot Id
O43447
Target Species
Human
Target Name
PPIH
Target Full Name
Peptidyl-prolyl cis-trans isomerase H
Target Function
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.
Target Subcellular Location
Nucleus speckle. Cytoplasm. Note=Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic.
Target Protein Families
Cyclophilin-type PPIase family, PPIase H subfamily
Target Synonyms
Cyclophilin H; CYP-20; CypH; Peptidyl prolyl cis trans isomerase H; Peptidyl-prolyl cis-trans isomerase H; Peptidylprolyl isomerase H; PPIase H; PPIH; PPIH_HUMAN; RGD1564921; Rotamase H; Small nuclear ribonucleoprotein particle specific cyclophilin H; Small nuclear ribonucleoprotein particle-specific cyclophilin H; SnuCyp 20; U snRNP associated cyclophilin SnuCyp 20; U-snRNP-associated cyclophilin SnuCyp-20; USA CYP; USA-CYP; USACYP
Target Background
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.
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