Rabbit anti-Human PPIL2 Polyclonal Antibody

Uniprot Id

Q13356

Target Species

Human

Target Name

PPIL2

Target Full Name

RING-type E3 ubiquitin-protein ligase PPIL2

Target Function

Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.

Target Subcellular Location

Nucleus.

Target Protein Families

Cyclophilin-type PPIase family, PPIL2 subfamily

Target Tissue Specificity

Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node

Target Synonyms

LJ39930; CYC4; Cyclophilin 60; Cyclophilin 60kDa; Cyclophilin like protein Cyp 60; Cyclophilin-60; Cyclophilin-like protein Cyp-60; CYP60; hCyP 60; MGC33174; MGC787; Peptidyl prolyl cis trans isomerase like 2; Peptidyl-prolyl cis-trans isomerase-like 2; Peptidylprolyl cis trans isomerase; Peptidylprolyl isomerase cyclophilin like 2; PPIase; PPIL2; PPIL2_HUMAN; Rotamase; Rotamase PPIL2

Target Background

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene.