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The antibody against PPP1R14A was raised in rabbit using the Recombinant Human Protein phosphatase 1 regulatory subunit 14A protein (1-147AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against PPP1R14A was raised in rabbit using the Recombinant Human Protein phosphatase 1 regulatory subunit 14A protein (1-147AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using PPP1R14A Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PPP1R14A Antibody at dilution of 1:1002
| Cat.No | ADC-18690A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PPP1R14A |
| Target Synonyms | 17-KD antibody; PP14A_HUMAN antibody; PPP1INL antibody; Ppp1r14a antibody; Protein kinase C-potentiated inhibitor of protein phosphatase 1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein phosphatase 1 regulatory subunit 14A protein (1-147AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96A00 |
Uniprot Id
Q96A00
Target Species
Human
Target Name
PPP1R14A
Target Full Name
Protein phosphatase 1 regulatory subunit 14A
Target Function
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Target Subcellular Location
Cytoplasm.
Target Protein Families
PP1 inhibitor family
Target Tissue Specificity
Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.
Target Synonyms
17 kDa PKC-potentiated inhibitory protein of PP1; 17-KDa protein; 17kDa PKC potentiated inhibitory protein of PP1; CPI 17 alpha; CPI 17; CPI 17alpha; CPI-17; CPI17 alpha; CPI17; PKC potentiated inhibitory protein of PP1; PKC potentiated inhibitory protein of PP1, 17-KD; PP14A_HUMAN; PPP1INL; Ppp1r14a; Protein kinase C-potentiated inhibitor of protein phosphatase 1, 17-KD; Protein kinase C-potentiated inhibitor protein of 17 kDa; Protein phosphatase 1; Protein phosphatase 1 regulatory (inhibitor) subunit 14A; Protein phosphatase 1 regulatory subunit 14A; Regulatory subunit 14A
Target Background
The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
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