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The antibody against PPP3CB was raised in rabbit using the Human PPP3CB as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against PPP3CB was raised in rabbit using the Human PPP3CB as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-52260A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PPP3CB |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Human PPP3CB | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P16298 |
Uniprot Id
P16298
Target Species
Human
Target Name
PPP3CB
Target Full Name
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Target Function
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.
Target Subcellular Location
Cytoplasm.
Target Protein Families
PPP phosphatase family, PP-2B subfamily
Target Synonyms
Calcineurin A beta; Calcineurin A2; Calcineurin B; formerly; Calmodulin dependent calcineurin A subunit beta isoform; Calmodulin-dependent calcineurin A subunit beta isoform; CALNA 2; CALNA2; CALNB; CAM PRP catalytic subunit; CAM-PRP catalytic subunit; CNA2; CnAbeta; PP2BB_HUMAN; PP2Bbeta; PPP3CB; Protein phosphatase 2B; catalytic subunit; beta isoform; formerly ; Protein phosphatase 3 (formerly 2B) catalytic subunit beta isoform; Protein phosphatase 3 catalytic subunit beta isoform; Protein phosphatase 3 catalytic subunit beta isozyme; Serine/threonine protein phosphatase 2B catalytic subunit beta isoform; Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Target Background
Enables several functions, including calmodulin binding activity; calmodulin-dependent protein phosphatase activity; and protein phosphatase 2B binding activity. Involved in calcineurin-NFAT signaling cascade; positive regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in cytoplasm. Part of calcineurin complex. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia.
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