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The antibody against PRDM12 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 100-330 of human PRDM12 (NP_067632.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PRDM12 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 100-330 of human PRDM12 (NP_067632.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-07068A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PRDM12 |
| Target Synonyms | PFM9; HSAN8; PRDM12 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 100-330 of human PRDM12 (NP_067632.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9H4Q4 | Immunogen Sequence |
Uniprot Id
Q9H4Q4
Target Species
Human
Target Name
PRDM12
Target Full Name
PR domain zinc finger protein 12
Target Function
Involved in the positive regulation of histone H3-K9 dimethylation.
Target Involvement
Neuropathy, hereditary sensory and autonomic, 8 (HSAN8)
Target Subcellular Location
Nucleus.
Target Protein Families
Class V-like SAM-binding methyltransferase superfamily
Target Tissue Specificity
Not found in adult tissues except in dorsal root ganglia.
Target Synonyms
PRDM12; PFM9PR domain zinc finger protein 12; EC 2.1.1.-; PR domain-containing protein 12
Target Background
This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia.
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