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The antibody against PRDM12 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human PRDM12. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IF, ELISA.
The antibody against PRDM12 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human PRDM12. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IF, ELISA.
$167.00
Western Blot analysis of HuvEC cells using PRDM12 Polyclonal Antibody
| Cat.No | ADC-37798A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PRDM12 |
| Target Synonyms | PRDM12 antibody; PFM9PR domain zinc finger protein 12 antibody; EC 2.1.1.- antibody; PR domain-containing protein 12 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human PRDM12. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9H4Q4 |
Uniprot Id
Q9H4Q4
Target Species
Human
Target Name
PRDM12
Target Full Name
PR domain zinc finger protein 12
Target Function
Involved in the positive regulation of histone H3-K9 dimethylation.
Target Involvement
Neuropathy, hereditary sensory and autonomic, 8 (HSAN8)
Target Subcellular Location
Nucleus.
Target Protein Families
Class V-like SAM-binding methyltransferase superfamily
Target Tissue Specificity
Not found in adult tissues except in dorsal root ganglia.
Target Synonyms
PRDM12; PFM9PR domain zinc finger protein 12; EC 2.1.1.-; PR domain-containing protein 12
Target Background
This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia.
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