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The antibody against PROC was raised in rabbit using the Recombinant Human Vitamin K-dependent protein C protein (288-409AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against PROC was raised in rabbit using the Recombinant Human Vitamin K-dependent protein C protein (288-409AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human liver tissue using PROC Antibody at dilution of 1:100
Immunofluorescent analysis of Hela cells using PROC Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-12487A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PROC |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Vitamin K-dependent protein C protein (288-409AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P04070 |
Uniprot Id
P04070
Target Species
Human
Target Name
PROC
Target Full Name
Vitamin K-dependent protein C
Target Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Target Involvement
Thrombophilia due to protein C deficiency, autosomal dominant (THPH3); Thrombophilia due to protein C deficiency, autosomal recessive (THPH4)
Target Subcellular Location
Secreted. Golgi apparatus. Endoplasmic reticulum.
Target Protein Families
Peptidase S1 family
Target Tissue Specificity
Plasma; synthesized in the liver.
Target Research Area
Others
Target Synonyms
Activation peptide; Anticoagulant protein C; APC; Autoprothrombin IIA; Blood coagulation factor XIV; EC 3.4.21.69; PC; proC; PROC_HUMAN; PROC1 ; Protein C (inactivator of coagulation factors Va and VIIIa); THPH3; THPH4; Vitamin K dependent protein C
Target Background
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
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