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The antibody against PROC was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Protein C. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against PROC was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Protein C. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
$167.00
Western Blot analysis of K562 cells using Protein C Polyclonal Antibody
| Cat.No | ADC-37128A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PROC |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human Protein C. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P04070 |
Uniprot Id
P04070
Target Species
Human
Target Name
PROC
Target Full Name
Vitamin K-dependent protein C
Target Function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Target Involvement
Thrombophilia due to protein C deficiency, autosomal dominant (THPH3); Thrombophilia due to protein C deficiency, autosomal recessive (THPH4)
Target Subcellular Location
Secreted. Golgi apparatus. Endoplasmic reticulum.
Target Protein Families
Peptidase S1 family
Target Tissue Specificity
Plasma; synthesized in the liver.
Target Research Area
Others
Target Synonyms
Activation peptide; Anticoagulant protein C; APC; Autoprothrombin IIA; Blood coagulation factor XIV; EC 3.4.21.69; PC; proC; PROC_HUMAN; PROC1 ; Protein C (inactivator of coagulation factors Va and VIIIa); THPH3; THPH4; Vitamin K dependent protein C
Target Background
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
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