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The antibody against PROCR was raised in rabbit using the Recombinant Human Endothelial protein C receptor protein (18-210AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against PROCR was raised in rabbit using the Recombinant Human Endothelial protein C receptor protein (18-210AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human lung tissue using PROCR Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using PROCR Antibody at dilution of 1:1002
| Cat.No | ADC-50950A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PROCR |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Endothelial protein C receptor protein (18-210AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UNN8 |
Uniprot Id
Q9UNN8
Target Species
Human
Target Name
PROCR
Target Full Name
Endothelial protein C receptor
Target Function
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
Target Research Area
Cardiovascular
Target Synonyms
Activated protein C receptor; APC receptor; APCR; bA42O4.2; CCCA ; CCD41; CD201; CD201 antigen ; cell cycle; centrosome-associated protein; Cell cycle; centrosome-associated protein; centrocyclin; Endothelial cell protein C receptor; Endothelial protein C receptor; EPCR; EPCR_HUMAN; MGC23024; PROCR; Protein C receptor; endothelial
Target Background
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer.
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