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The antibody against Prolactin Receptor was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 25-234 of human Prolactin Receptor (NP_000940.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against Prolactin Receptor was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 25-234 of human Prolactin Receptor (NP_000940.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06421A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Prolactin Receptor |
| Target Synonyms | HPRL; MFAB; hPRLrI; RI-PRLR; Prolactin Receptor | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, MCF7, Mouse ovary | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 25-234 of human Prolactin Receptor (NP_000940.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P16471 | Immunogen Sequence |
Uniprot Id
P16471
Target Species
Human
Target Name
PRLR
Target Full Name
Prolactin receptor
Target Function
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Target Involvement
Multiple fibroadenomas of the breast (MFAB); Hyperprolactinemia (HPRL)
Target Subcellular Location
Membrane; Single-pass type I membrane protein.; [Isoform 7]: Secreted.
Target Protein Families
Type I cytokine receptor family, Type 1 subfamily
Target Tissue Specificity
Expressed in breast, placenta, kidney, liver and pancreas.
Target Synonyms
PRLR; Prolactin receptor; PRL-R
Target Background
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer.
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