Rabbit anti-Human PROX1 Monoclonal Antibody

Uniprot Id

Q92786

Target Species

Human

Target Name

PROX1

Target Full Name

Prospero homeobox protein 1

Target Function

Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

Target Subcellular Location

Nucleus.

Target Protein Families

Prospero homeodomain family

Target Tissue Specificity

Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.

Target Synonyms

Homeobox prospero like protein; Homeobox prospero like protein PROX1; Homeobox prospero-like protein PROX1; Prospero homeobox 1; Prospero homeobox protein 1; Prospero related homeobox 1; prospero-related homeobox gene 1; PROX 1; PROX-1; PROX1; PROX1_HUMAN; zgc:111888

Target Background

The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants.