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The antibody against PRPF4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PRPF4 (NP_004688.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against PRPF4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PRPF4 (NP_004688.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-03603A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PRPF4 |
| Target Synonyms | PRP4; RP70; HPRP4; Prp4p; HPRP4P; SNRNP60; PRPF4 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | DU145, HT-29, MCF7, Mouse spleen, Mouse testis, Mouse thymus, Rat spleen, SKOV3, SW480 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PRPF4 (NP_004688.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O43172 | Immunogen Sequence |
Uniprot Id
O43172
Target Species
Human
Target Name
PRPF4
Target Full Name
U4/U6 small nuclear ribonucleoprotein Prp4
Target Function
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
Target Involvement
Retinitis pigmentosa 70 (RP70)
Target Subcellular Location
Nucleus. Nucleus speckle.
Target Synonyms
hPrp4; HPRP4P ; PRP4 ; PRP4 homolog; PRP4 pre mRNA processing factor 4 homolog (yeast); PRP4/STK/WD splicing factor; PRP4_HUMAN; Prp4p ; PRPF4; RP70; SNRNP60; U4/U6 small nuclear ribonucleoprotein Prp4; U4/U6 snRNP 60 kDa protein; WD splicing factor Prp4
Target Background
The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gene.
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