Rabbit anti-Human PRSS2 Monoclonal Antibody

The antibody against PRSS2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human PRSS2 (P07478) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-14350A

Number

Cat.No	ADA-14350A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	PRSS2
Target Synonyms	TRY2; TRY8; TRYP2; PRSS2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse pancreas, Rat pancreas	Application	ELISA, WB, IHC-P

Cat.No

ADA-14350A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

PRSS2

Target Synonyms

TRY2; TRY8; TRYP2; PRSS2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse pancreas, Rat pancreas

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PRSS2 (P07478).	Target Species	Human
Immunogen Sequence	MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYN	Uniprot ID	P07478

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PRSS2 (P07478).

Target Species

Human

Immunogen Sequence

MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYN

Uniprot ID

P07478

Background Information

Uniprot Id

P07478
Target Species

Human
Target Name

PRSS2
Target Full Name

Trypsin-2
Target Function

In the ileum, may be involved in defensin processing, including DEFA5.
Target Subcellular Location

Secreted, extracellular space.
Target Protein Families

Peptidase S1 family
Target Tissue Specificity

Expressed in Paneth cells, at the base of small intestinal crypts.
Target Research Area

Cell Biology
Target Synonyms

(Anionic trypsinogen)(Serine protease 2)(Trypsin II)
Target Background

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.

Rabbit anti-Human PRSS2 Monoclonal Antibody

Specifications

Immunogen Information

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