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The antibody against PRUNE1 was raised in rabbit using the Recombinant Human Exopolyphosphatase PRUNE1 protein (1-168AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF, IP.
The antibody against PRUNE1 was raised in rabbit using the Recombinant Human Exopolyphosphatase PRUNE1 protein (1-168AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF, IP.
$299.00
| Cat.No | ADC-32820A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PRUNE1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB, IP | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Exopolyphosphatase PRUNE1 protein (1-168AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q86TP1 |
Uniprot Id
Q86TP1
Target Species
Human
Target Name
PRUNE1
Target Full Name
Exopolyphosphatase PRUNE1
Target Function
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization.
Target Involvement
Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (NMIHBA)
Target Subcellular Location
Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
Target Protein Families
PPase class C family, Prune subfamily
Target Tissue Specificity
Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.
Target Research Area
Cancer
Target Synonyms
DRES-17; DRES17; Drosophila-related expressed sequence 17; hPrune; HTcD37; Protein prune homolog; PRUNE; Prune homolog; PRUNE like protein; PRUNE_HUMAN; TcD37 homolog
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