Rabbit anti-Human PSIP1 Polyclonal Antibody

The antibody against PSIP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 301-530 of human PSIP1 (NP_150091.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01284A

Number

Cat.No	ADA-01284A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PSIP1
Target Synonyms	p52; p75; PAIP; DFS70; LEDGF; PSIP2; PSIP1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, NIH/3T3, HepG2, Jurkat, Mouse brain, Mouse thymus, SW480	Application	ELISA, WB

Cat.No

ADA-01284A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PSIP1

Target Synonyms

p52; p75; PAIP; DFS70; LEDGF; PSIP2; PSIP1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, NIH/3T3, HepG2, Jurkat, Mouse brain, Mouse thymus, SW480

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 301-530 of human PSIP1 (NP_150091.2).	Target Species	Human
Uniprot ID	O75475	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 301-530 of human PSIP1 (NP_150091.2).

Target Species

Human

Uniprot ID

O75475

Immunogen Sequence

Background Information

Uniprot Id

O75475
Target Species

Human
Target Name

PSIP1
Target Full Name

PC4 and SFRS1-interacting protein
Target Function

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Target Involvement

A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1 exon 4.
Target Subcellular Location

Nucleus. Note=Remains chromatin-associated throughout the cell cycle.
Target Protein Families

HDGF family
Target Tissue Specificity

Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), i
Target Synonyms

CLL associated antigen KW 7; CLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; DFS70; LEDGF; Lens epithelium derived growth factor; Lens epithelium-derived growth factor; MGC74712; p52; p75; PAIP; PC4 and SFRS1 interacting protein 1; PC4 and SFRS1 interacting protein 2; PC4 and SFRS1 interacting protein; PC4 and SFRS1-interacting protein; PSIP 1; PSIP 2; Psip1; PSIP1_HUMAN; PSIP2; Transcriptional coactivator p75/p52

Rabbit anti-Human PSIP1 Polyclonal Antibody

Specifications

Immunogen Information

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