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The antibody against PSMA8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PSMA8 (NP_653263.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PSMA8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PSMA8 (NP_653263.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00655A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PSMA8 |
| Target Synonyms | PSMA7L; PSMA8 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | K-562, Mouse testis, Mouse thymus, Rat thymus | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PSMA8 (NP_653263.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8TAA3 | Immunogen Sequence |
Uniprot Id
Q8TAA3
Target Species
Human
Target Name
PSMA8
Target Full Name
Proteasome subunit alpha-type 8
Target Function
Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complexe that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.
Target Subcellular Location
Nucleus.
Target Protein Families
Peptidase T1A family
Target Synonyms
PSMA8; PSMA7L; Proteasome subunit alpha-type 8; EC 3.4.25.1; Proteasome alpha 4 subunit; Alpha4s; Proteasome subunit alpha-type 7-like
Target Background
Predicted to be involved in meiotic cell cycle and proteasomal protein catabolic process. Located in extracellular exosome and nucleus.
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