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The antibody against PSRC1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human PSRC1 (NP_001005290.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against PSRC1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human PSRC1 (NP_001005290.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03766A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PSRC1 |
| Target Synonyms | DDA3; FP3214; PSRC1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, MCF7 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human PSRC1 (NP_001005290.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6PGN9 | Immunogen Sequence |
Uniprot Id
Q6PGN9
Target Species
Human
Target Name
PSRC1
Target Full Name
Proline/serine-rich coiled-coil protein 1
Target Function
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
Target Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.
Target Protein Families
PSRC1 family
Target Tissue Specificity
Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle.
Target Synonyms
DDA3; DDA3; mouse; homolog of; Differential display and activated by p53; FP3214; OTTHUMP00000013785; OTTHUMP00000013786; p53-regulated DDA3; Proline/serine-rich coiled-coil 1; Proline/serine-rich coiled-coil protein 1; PSRC1; PSRC1_HUMAN
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