Rabbit anti-Human PTCH1 Polyclonal Antibody

Uniprot Id

Q13635

Target Species

Human

Target Name

PTCH1

Target Full Name

Protein patched homolog 1

Target Function

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

Target Involvement

Basal cell nevus syndrome (BCNS); Basal cell carcinoma (BCC); Holoprosencephaly 7 (HPE7)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Patched family

Target Tissue Specificity

In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin.

Target Synonyms

A230106A15Rik; BCNS; FLJ26746; FLJ42602; Holoprosencephaly 7; HPE7; mes; NBCCS; OTTHUMP00000021709 ; OTTHUMP00000021710 ; Patched ; Patched (Drosophila) homolog ; Patched 1; Patched homolog (Drosophila); Patched homolog 1 (Drosophila); Patched homolog 1; Patched protein homolog 1; Protein patched homolog 1; PTC; PTC1; PTC1_HUMAN; PTCH ; PTCH protein +12b ; PTCH protein +4' ; PTCH protein -10 ; PTCH protein; ptch1; PTCH1 protein ; PTCH11; Ptch2

Target Background

This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly.